Stimulating Satellite Cell Proliferation

Sustained tgfβ signaling in aged muscle is expected to decrease satellite cell proliferation stimulate proliferation of fibroblasts in skeletal muscle and increase expression of ecm proteins.

Stimulating satellite cell proliferation. They have the potential to provide additional myonuclei to their parent muscle fiber or return to a quiescent. Electrical stimulation hu es not only prevented the decline of the satellite cell pool fig. Zinc may increase bone formation through stimulating cell proliferation alkaline phosphatase activity and collagen synthesis in osteoblastic mc3t3 e1 cells nutr res pract. Myosatellite cells also known as satellite cells or muscle stem cells are small multipotent cells with very little cytoplasm found in mature muscle.

Luate the changes in satellite cell proliferation after electrical stimulation in nerve injury and to determine whether these changes are related to the restoration of myofiber cross section area csa. Electrical stimulation hu es not only prevented the decline of the satellite cell pool but also significantly induced proliferation of satellite cells brdu pax7 p 0 001. Epub 2010 oct 26. Satellite cells are precursors to skeletal muscle cells able to give rise to satellite cells or differentiated skeletal muscle cells.

Methods sciatic nerve crush injury was performed in 48 male sprague dawley rats. In half 24 48 of the rats the gastrocnemius was electrically stimulated transcutaneously on a daily basis. Increased tgfβ signaling inhibits satellite cell activation and proliferation allen and boxhorn 1987 1989. This stimulation parameter led to a 1 2 fold increase in satellite cell proliferation and was effective in rescuing cells from apoptosis.

Authors hyun ju seo 1. Compared to the hu group the ratio of brdu pax7 nuclei within the total pax7 population in the hu es group was increased by 80 2 6 8. 6 1 upon stimulation from exercise or following muscle injury satellite cells become activated and enter mitosis undergoing cellular division and giving rise to myogenic. Compared to the hu group the ratio of brdu pax7 nuclei within the total pax7 population in the hu es group was increased by 80 2 6 8.

Testosterone increases neurotransmitter levels at the muscle fiber site stimulates gh responses in the anterior pituitary interacts with nuclear receptors in dna and modulates satellite cell activity through increased igf 1 production and androgen receptor density. Rathbone et al 2011. Sciatic nerve crush injury was performed in 48 male sprague dawley rats. Valuate the changes in satellite cell proliferation after electrical stimulation in nerve injury and to determine whether these changes are related to the restoration of myofiber cross section area csa.

Besides satellite cells in the atrophic muscles required different stimulation protocols for different cellular activities such as activation proliferation and myogenic differentiation. Basically the big t optimizes satellite cell proliferation and differentiation.